WebNov 8, 2012 · It is well-known that stem cells are tightly regulated by a combination of physical and chemical factors from their complex extracellular surroundings; thus, … WebNov 30, 2015 · The extracellular matrix, a microenvironment of proteins and polymers that surrounds and connects cells, impacts a range of cellular behaviors including differentiation. For about a decade, researchers have been able to direct the fate of stem cells by tuning the mechanical stiffness of synthetic microenvironments such as hydrogels. Stem cells ...
Designing biomaterials to direct stem cell fate - PubMed
WebSep 26, 2011 · MP Lutolf, PM Gilbert, HM Blau, Designing materials to direct stem-cell fate. Nature 462, 433–441 (2009). Crossref. PubMed. Google Scholar. 14. T Lecuit, PF Lenne, Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis. Nat Rev Mol Cell Biol 8, 633–644 (2007). WebNov 27, 2012 · It is well-known that stem cells are tightly regulated by a combination of physical and chemical factors from their complex extracellular surroundings; thus, … floor protection mitre 10
Designing materials to direct stem-cell fate Nature
WebFeb 2, 2024 · Most design strategies for fabricating stem cell-laden tissue engineered scaffolds can be classified into one of the two categories. The first approach, top-down, focuses on designing the extracellular environment to contain the appropriate signals for guiding the differentiation of stem cells towards the lineage of choice. WebNov 8, 2012 · Biomaterials for controlling stem cell fate. Biomaterials for stem cells have become an important part of regenerative medicine because they can serve as a biomimetic platform for relevant biological studies. 3 Furthermore, these materials can ultimately be used as scaffolds for constructing artificial tissues or organs for clinical applications. To … WebNov 25, 2009 · Biomaterials are rapidly being developed to display and deliver stem-cell-regulatory signals in a precise and near-physiological fashion, and serve as powerful … floor protection mats office chairs