Medial smooth muscle cells
WebSep 30, 2024 · Vascular smooth muscle cells (VSMCs) are the predominant cell type in collateral arteries and respond to altered blood flow and inflammatory conditions after an arterial occlusion by switching their phenotype between quiescent contractile and proliferative synthetic states. WebFeb 1, 1999 · The expression of VCAM-1 on medial smooth muscle cells occurred prior to or coincident with mononuclear cell infiltration. In atherosclerotic vessels, VCAM-1 expression was detected in medial smooth muscle cells at the base of the lesions as well as in the fibrous cap [17].
Medial smooth muscle cells
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The vascular smooth muscle cell (SMC) is a differentiated cell type located within the medial layer of arteries and veins and expressing a unique repertoire of proteins (eg, MYH11 [smooth muscle myosin heavy chain], ACTA2 [smooth muscle alpha-actin], TAGLN [sm22 alpha], and MYOCD [myocardin]) required for … See more The need for unambiguous and definitive tracking of SMC fate arose from the following observations4: First, studies have demonstrated the loss of expression of SMC contractile genes, and the repression of their … See more Since the 1970’s, the mechanisms underlying SMC participation in intimal proliferation during atherosclerotic or after vascular injury have been a major focus of research. In 1973, Earl … See more The field has positioned itself at the crossroads of lineage tracing and single-cell transcriptomics to study phenotypic diversity and phenotypic evolution of SMC during vascular disease and remodeling. We are in an exciting … See more A potential explanation for SMC oligoclonal investment of atherosclerotic plaques is the predisposition of a distinct medial SMC subpopulation. Implicit in this postulate is the existence of SMC heterogeneity within … See more WebApr 14, 2024 · Isolated murine CREB-null smooth muscle cells exhibited serum-independent proliferation and hypertrophy in vitro and medium conditioned by CREB-null smooth …
WebA two- to fourfold increase in elastin production was observed in pulmonary artery tissue and medial smooth muscle cells from hypertensive calves. This stimulation of elastin production was accompanied by a corresponding increase in elastin messenger RNA consistent with regulation at the transcriptional level. WebVascular medial smooth muscle cells migrate, proliferate and transform to foam cells in the process of atherosclerosis. We have reported that the intimal smooth muscle cells express proto-oncogene c-fms, a characteristic gene of monocyte-macrophages, which is not normally expressed in medial smooth muscle cells.
WebOct 4, 2024 · Smooth Muscle Definition. Smooth muscle is a type of muscle tissue which is used by various systems to apply pressure to vessels and organs. Smooth muscle is composed of sheets or strands of smooth … WebJan 27, 2024 · Smooth muscle cells (SMCs) are the primary cell type in the pre-atherosclerotic intima, a state known as diffuse intimal thickening (DIT), and in all stages of human atherosclerotic plaque development. 1 SMCs are not terminally differentiated and can change their phenotype in response to environmental cues including growth …
WebBasic fibroblast growth factor (FGF2) is a potent mitogen for medial smooth muscle cells and is necessary for their proliferation after balloon catheter injury; however, intimal smooth muscle cells do not require FGF2 for their proliferation, and they respond only weakly to exogenous FGF2. The present study examined the activation of extracellular signal …
WebNov 27, 1996 · Smooth muscle cell (SMC) migration from the medial layer into the intima is a characteristic feature of transplant vasculopathy and is thought to be regulated by locally produced cytokines. lawn care grass imagesWebDysregulated mineral metabolism and the elevated levels of circulating calcium (Ca) and phosphate (Pi) are key factors for the initiation and progression of VC in CKD since major resident cells in the media layer of blood vessels, vascular smooth muscle cells (VSMCs), are sensitive to these factors. 4,5 VSMCs can undergo trans-differentiation ... kaiser women\u0027s fitness festivalWebJul 18, 2024 · Smooth muscle is found throughout the body where it serves a variety of functions. It is in the stomach and intestines where it helps with digestion and nutrient … kaiser willys jeep parts and accessorieslawn care griffin gaWebAbstract. Background: Abdominal aortic aneurysms (AAAs) are associated with aging and atherosclerosis. AAAs arise through a degenerative process characterized in part by … kaiser with medicaid dentalWebThe tunica media is characterized by the presence of concentric layers of vascular smooth muscle cells (VSMCs) and elastin-rich extracellular matrix. It is the final recipient of signals regulating the vascular tone and is separated from adventitia by the external elastic lamina. • kaiser wolf authorWebApr 14, 2024 · PH is characterized by thickening of the pulmonary artery (PA) wall and persistent vasoconstriction of the pulmonary vasculature. 2 Thickening of the PA wall is the result of medial smooth muscle cell (SMC) proliferation and hypertrophy, and extracellular matrix production. In addition, contractile SMCs appear around previously … kaiser woodbridge pharmacy phone number