Webimatinib exposure (area under the curve, AUC) in 58 patients. Plasma-free concentration was deduced from a model incorporating plasma levels of alpha 1-acid glycoprotein. … WebFeb 23, 2010 · The cutoff value of 20 ng ml −1 free imatinib plasma trough level corresponded to the best sensitivity (86%) and specificity (100%). The geometric average …
Imatinib pharmacokinetics and its correlation with response and …
WebOct 5, 2024 · Plasma samples were collected at steady-state at varying times after dosing. Total and unbound imatinib concentrations were determined for 475 and 150 samples, respectively, with a median of four … WebMay 6, 2008 · Relationship of imatinib-free plasma levels and target genotype with efficacy and tolerability. ... Lausanne, Switzerland. ORCIDs linked to this article. Widmer N, 0000-0001-7392-2418, Pharmacie des Hôpitaux de l'Est Lémanique; Csajka C, 0000-0002-0660-082X, Centre Hospitalier Universitaire Vaudois; hollister.ch
Relationship of imatinib-free plasma levels and target genotype …
WebApr 29, 2024 · Discussion. The results of the present study indicated that ABCG2 c.421C>A single nucleotide polymorphism significantly influenced imatinib pharmacokinetics in relatively low AGP plasma levels. However, neither the ABCG2 nor the ABCB1 polymorphism independently affected imatinib pharmacokinetics suggesting that the plasma AGP level … WebRelationship of imatinib-free plasma levels and target genotype with efficacy and tolerability. British Journal of Cancer, 2008. Maria Debiec-Rychter. Nicolas Widmer. WebOur results suggest that imatinib dosage of 400 mg/day is recommended for a patient with a large BSA (≥1.56 m2) and that of 300 mg/day might be suf … Imatinib plasma levels … human resources vision board