Stat1 binding motif

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August undefined, 2024

WebNational Center for Biotechnology Information WebAug 27, 2010 · How to identify true transcription factor binding sites on the basis of sequence motif information (e.g., motif pattern, location, combination, etc.) is an important question in bioinformatics. We present “PeakRegressor,” a system that identifies binding motifs by combining DNA-sequence data and ChIP-Seq data. PeakRegressor uses L1 …

The Stat1 Binding Motif of the Interferon-γ Receptor Is …

WebApr 4, 2024 · STAT1 binding sites were identified on the putative miR-7 promoter and stimulation of fibroblasts with the inflammatory cytokine, interferon-gamma (IFN-gamma), … WebSep 1, 1998 · Stat1 is phosphorylated on a single residue, Tyr-701, in response to stimulation by a number of ligands including interferons (IFNs), interleukin 6 (IL-6), and epidermal growth factor (8–11). The phosphorylation on the Tyr-701 residue of Stat1 is required for its nuclear translocation, dimerization, DNA binding, and gene activation (8, 12). symbolism of seeing a fox

Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 …

WebNov 26, 2024 · Furthermore, tripartite interaction motif 40 (TRIM40) ... However, it was recently shown that at isolated IRF1 sites lacking STAT1-binding sequences, 25% undergo inducible histone acetylation, 31% exhibit constitutive histone acetylation, and 44% show no histone acetylation (orphan sites) . Interestingly, most isolated IRF1 sites that are ... WebMar 21, 2024 · STAT1 (Signal Transducer And Activator Of Transcription 1) is a Protein Coding gene. Diseases associated with STAT1 include Immunodeficiency 31C and … WebFeb 17, 2024 · STAT1 GOF Mutants Show a Loss of Specificity for the Canonical STAT1 Binding Motifs. Together, the previous analyses indicate that GOFs hyperactivate the commonly up-regulated genes compared to STAT1 WT, with the exception of T419R . ... symbolism of seeing a hawk

Noncanonical STAT1 phosphorylation expands its ... - Science

Attenuation of Dupuytren’s fibrosis via targeting of the STAT1 ...

WebMay 21, 2014 · In this study, we have characterized a sequence motif in the STAT1 linker domain which is highly conserved among the seven human STAT proteins and includes surface-exposed residues in close proximity to the bound DNA. WebThe cross-talk between STAT1 and STAT3 in cancer has not been fully demonstrated. Materials and methods: Esophageal squamous cell carcinoma (ESCC) was used as a model to examine STAT1-STAT3 cross-regulation in cancer. We detected STAT1-STAT3 binding by co-immunoprecipitation (co-IP) and measured the transcription activity by using a … symbolism of seeing a white buffaloWebOct 6, 2013 · To determine the Stat-dependent transcriptional network and its functions in inflammation, we investigated the genomic distribution of the Stat1, Stat3, and Stat5 binding sites and the role of Stats in the control of the gene expression in LPS-stimulated primary microglial cultures. symbolism of single crow

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Stat1 binding motif

Inhibition of Stat1-mediated gene activation by PIAS1 PNAS

WebMay 21, 2014 · For transfection of untagged STAT1 in U3A cells, the expression plasmid pcDNA3.1 (Invitrogen) was used, which coded for full-length human STAT1 cDNA. DNA … WebJan 24, 2024 · Binding of IFN-γ to the cell surface receptor triggers JAK-induced tyrosine phosphorylation of STAT1 (1). Through spontaneous dissociation and reassociation, the activated STAT1 molecules constantly oscillate between the parallel and antiparallel dimer conformation (2).

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WebNov 26, 2024 · STAT1 participates in all major histocompatibility complex (MHC)-dependent antigen presentation processes. 86 In addition, STAT1 is involved in the early … WebAug 27, 2010 · In the case of STAT1, it is clear that our approach correctly identifies the classical GAS motif TTC[TC]N[GA]GAA as the main binding motif . Meanwhile, the RNA …

WebHowever, there is reduced binding of STAT1 homodimers to target gamma activated sequence (GAS) elements in the presence of IE1. Co-immunoprecipitation studies failed to support a direct interaction between IE1 and STAT1, although these studies revealed that the C-terminal region of IE1 was required for interaction with STAT2. ... (Activ Motif ... WebJun 11, 2007 · STAT1 complexes activate or repress transcription primarily by the homodimer binding to IFN-γ activation site (GAS) elements, but also to interferon …

WebThe Stat1 Binding Motif of the Interferon-γ Receptor Is Sufficient to Mediate Stat5 Activation and Its Repression by SOCS3* - Journal of Biological Chemistry MECHANISMS OF SIGNAL TRANSDUCTION Volume 276, … WebMar 9, 2024 · Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling Poxviruses and paramyxoviruses use a …

WebJul 10, 2024 · In summary, these data indicate enhanced STAT1 binding at the IL-13Rα1 gene locus, specifically in Dupuytren’s myofibroblasts, which may be the cause of enhanced receptors’ activity in disease. STAT inhibition in Dupuytren’s disease: Translational targeting

WebApr 19, 2024 · This suggests a competition of STAT1/3 for phospho-tyrosine motifs at the cytoplasmic domain of cytokine receptors regulated by their different binding rate constants (on and off rates). Indeed, different STAT1 or STAT3 binding affinities have been assessed in vitro for the phospho-tyrosines on GP130 (Wiederkehr-Adam et al., 2003). symbolism of shoes in house on mango streetWebJan 9, 2024 · The interaction with STAT1 is also mediated by the IF1 interface of IRF9, as the IF1-C mutant completely abolished STAT1 binding ( Fig. S3 C ). The 500-fold higher binding affinity for STAT2 likely explains why IRF9 constitutively interacts with STAT2 but not STAT1 in ISGF3 signaling ( 23 ). Table 2. Summary of ITC data Expand for more symbolism of slippers in pygmalionWebMar 9, 2024 · The STAT1-binding motif, described here, likely represents a striking example of convergent evolution in diverse virus families and has produced an unconventional binding mechanism to target STAT1. Consistent with the notion that SLiMs preferentially target proteins central to multiple networks ( Dyer et al., 2008 ), STAT1 is required for ISG ... tgs icd 10WebSTAT1 stimulated the expression of the genes encoding IL-12p40 and the protein ARID5A, which increased the stability of IL6 mRNA. Together, these findings suggest how endocytosed TLR4 contributes to proinflammatory cytokine production, which may have implications for the use of vaccine adjuvants that target this receptor. Abstract tgs indicatorWebJun 11, 2007 · Of the 34 loci known to contain STAT1 interferon-responsive binding sites, ChIP-seq found 24 (71%). ChIP-seq targets were enriched in sequences similar to known STAT1 binding motifs.... symbolism of snow whiteWebSep 6, 2012 · The most striking difference between the YY1 motif for sites where binding is associated with activation (Fig. 2 (b)) and those where binding is associated with repression (Fig. 2 (c)) occurs... tgsi gmbh bornheimWebFeb 2, 2013 · The MUC1-C cytoplasmic domain also functions as a substrate for EGFR phosphorylation on the Y 46 EKV motif . In turn, pYEKV functions as a binding site for the SRC SH2 domain (32; 33). ... MUC1-C associates with STAT1 in cells through direct binding of the MUC1-C cytoplasmic domain to the STAT1 DNA-binding domain . The interaction … tgs industrial supplies limited